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To delineate the clinical value of the TGFО pathway in breast cancer, we assessed the level of TGFBR2 expression and SMAD2 phosphorylation pSMAD2 by immunohistochemical staining of archived tissue sections of primary tumors using a cohort of 564 premenopausal patients enrolled in a randomized tamoxifen trial SBII 2, for study design see Supplementary Fig <a href=https://bestcialis20mg.com/>purchasing cialis online</a>